>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
--------------------MNGTE--GDNFYVPFSNKTG--LARSP-------------
-------------------------------YEYPQY-YLAEPW----------------
------KYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLF
G-FTVTMYTSMN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGN
F-RFGNTHAIMGVAFTWIMALAC-AAPPLVG-WS-----RYIPEGMQCSCGPDYYTLNPN
FNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKEAAAAQQESA----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFT--HQGSD-FGATFMTLPAF
FAKSSALYNPVIYILMNKQFRNCMITTL-----CCGKNPLGDDE-SG-ASTSKTEVSSVS
T-----------------------------------------------------------
-----------------------------------SPV-------SP-A
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
--------------------MNGTE--GPNFYVPFSNITG--VVRSP-------------
-------------------------------FEQPQY-YLAEPW----------------
------QFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFG
G-FTTTLYTSLH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSN
F-RFGENHAIMGVAFTWVMALAC-AAPPLVG-WS-----RYIPEGMQCSCGIDYYTLKPE
VNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESA----------------
------------------------------------------------------------
------------------------------------------------------------
-----TTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFT--HQGSN-FGPIFMTLPAF
FAKTASIYNPIIYIMMNKQFRNCMLTSL-----CCGKNPLGDDE-AS-ATASKTE-----
T-----------------------------------------------------------
-----------------------------------SQV-------AP-A
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
--------------------MNGTE--GINFYVPMSNKTG--VVRSP-------------
-------------------------------FEYPQY-YLAEPW----------------
------KYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACF
G-FTVTFYTAWN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGN
F-RFSATHAMMGIAFTWVMAFSC-AAPPLFG-WS-----RYMPEGMQCSCGPDYYTHNPD
YHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVREAAAQQQESA----------------
------------------------------------------------------------
------------------------------------------------------------
-----TTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFT--NKGAD-FTATLMAVPAF
FSKSSSLYNPIIYVLMNKQFRNCMITTI-----CCGKNPFGDEDVSSTVSQSKTEVSSVS
S-----------------------------------------------------------
-----------------------------------SQV-------SP-A
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
--------------------MNGTE--GKNFYVPMSNRTG--LVRSP-------------
-------------------------------FEYPQY-YLAEPW----------------
------QFKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCF
G-FTVTFYTAIN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS
F-KFSSSHAFAGIAFTWVMALAC-AAPPLFG-WS-----RYIPEGMQCSCGPDYYTLNPD
YNNESYVIYMFVCHFILPVAVIFFTYGRLVCTVKAAAAQQQDSA----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEREVTKMVILMVFGFLIAWTPYATVAAWIFF--NKGAD-FSAKFMAIPAF
FSKSSALYNPVIYVLLNKQFRNCMLTTI-----FCGKNPLGDDE-SSTVSTSKTEVSS--
------------------------------------------------------------
-------------------------------------V-------SP-A
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
--------------------MNGTE--GNNFYVPLSNRTG--LVRSP-------------
-------------------------------FEYPQY-YLAEPW----------------
------QFKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIMVCF
G-FTVTFYTAIN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS
F-KFSSTHASAGIAFTWVMAMAC-AAPPLVG-WS-----RYIPEGIQCSCGPDYYTLNPE
YNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKAAAAQQQDSA----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEREVTKMVILMVLGFLVAWTPYATVAAWIFF--NKGAA-FSAQFMAIPAF
FSKTSALYNPVIYVLLNKQFRSCMLTTL-----FCGKNPLGDEE-SSTVSTSKTEVSS--
------------------------------------------------------------
-------------------------------------V-------SP-A
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
--------------------MKQVPEFHEDFYIPIPLDINNLSAYSP-------------
-------------------------------FLVPQD-HLGNQG----------------
------IFMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIF
G-SPLSFYSFFN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGN
F-TFKTPHAIAGCILPWISALAA-SLPPLFG-WS-----RYIPEGLQCSCGPDWYTTNNK
YNNESYVMFLFCFCFAVPFGTIVFCYGQLLITLKLAAKAQADSA----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEREVTKMVVVMVLGFLVCWAPYASFSLWIVS--HRGEE-FDLRMATIPSC
LSKASTVYNPVIYVLMNKQFRSCMM-KM-----VCGKN-IEEDE-AS-TSSQVTQVSS--
------------------------------------------------------------
-------------------------------------V-------APEK
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
--------------------MRKMS--EEEFYL-FKNISS----VGP-------------
-------------------------------WDGPQY-HIAPVW----------------
------AFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIF
S-VFPVFVASCN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGN
F-RFSSKHALTVVLATWTIGIGV-SIPPFFG-WS-----RFIPEGLQCSCGPDWYTVGTK
YRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESA----------------
------------------------------------------------------------
------------------------------------------------------------
-----TTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVN--NRNHG-LDLRLVTIPSF
FSKSACIYNPIIYCFMNKQFQACIM-KM-----VCGKA-MTDES-DT-CSSQKTEVSTVS
S-----------------------------------------------------------
-----------------------------------TQV-------GP-N
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
-----------------------------------------------------DLAETVI
A-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN
V-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLKTSCGPDVFSGSSY
PGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEKEVTRMVVVMVLAFC----------------------------------
------------------------------------------------------------
------------------------------------------------------------
-------------------------------------------------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
MAQQWS-LQRLAGRHPQDSYEDSTQ--SSIFTYTNSNST-----RGP-------------
-------------------------------FEGPNY-HIAPRW----------------
------VYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVI
A-STISVVNQVY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGN
V-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-WS-----RYWPHGLKTSCGPDVFSGSSY
PGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESE----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAA--NPGYP-FHPLMAALPAF
FAKSATIYNPVIYVFMNRQFRNCILQLF-------GKKVDDGSE-LS--SASKTEVSSV-
------------------------------------------------------------
-----------------------------------SSV-------SP-A
>    10== Z68193   1 human Red Opsin <>[]
MAQQWS-LQRLAGRHPQDSYEDSTQ--SSIFTYTNSNST-----RGP-------------
-------------------------------FEGPNY-HIAPRW----------------
------VYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVI
A-STISIVNQVS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN
V-RFDAKLAIVGIAFSWIWSAVW-TAPPIFG-WS-----RYWPHGLKTSCGPDVFSGSSY
PGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESE----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAA--NPGYA-FHPLMAALPAY
FAKSATIYNPVIYVFMNRQFRNCILQLF-------GKKVDDGSE-LS--SASKTEVSSV-
------------------------------------------------------------
-----------------------------------SSV-------SP-A
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAVFAARRSRDD--DDTTR--GSVFTYTNTNNT-----RGP-------------
-------------------------------FEGPNY-HIAPRW----------------
------VYNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVETLV
A-STISVFNQIF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGN
I-KFDSKLAIIGIVFSWVWAWGW-SAPPIFG-WS-----RYWPHGLKTSCGPDVFSGSVE
LGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAIRAVAAQQKESE----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEREVSRMVVVMIVAFCICWGPYASFVSFAAA--NPGYA-FHPLAAALPAY
FAKSATIYNPVIYVFMNRQFRNCIMQLF-------GKKVDDGSE-AS--TTSRTEVSSVS
N-----------------------------------------------------------
-----------------------------------SSV-------AP-A
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
MA-AWE-AAFAARRRHEE--EDTTR--DSVFTYTNSNNT-----RGP-------------
-------------------------------FEGPNY-HIAPRW----------------
------VYNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVI
A-STISVINQIS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGN
I-KFDGKLAVAGILFSWLWSCAW-TAPPIFG-WS-----RYWPHGLKTSCGPDVFSGSSD
PGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAIRAVAAQQKESE----------------
------------------------------------------------------------
------------------------------------------------------------
-----STQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAA--NPGYA-FHPLAAALPAY
FAKSATIYNPIIYVFMNRQFRNCILQLF-------GKKVDDGSE-VS--T-SRTEVSSVS
N-----------------------------------------------------------
-----------------------------------SSV-------SP-A
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
------------------------M--SSNSSQAPPNGT-----PGP-------------
-------------------------------FDGPQWPYQAPQS----------------
------TYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLC
G-SSVSLSNNIN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGD
F-QFQRRHAVSGCAFTWGWALLW-SAPPLLG-WS-----SYVPEGLRTSCGPNWYTGGSN
--NNSYILSLFVTCFVLPLSLILFSYTNLLLTLRAAAAQQKEAD----------------
------------------------------------------------------------
------------------------------------------------------------
-----TTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVAT--HKGII-IQPVLASLPSY
FSKTATVYNPIIYVFMNKQFQSCLLEML-----CCGYQPQRTGK-AS--PGTPGPHADVT
A-----------------------------------------------------------
-----------------------------------AGLRNKVMPAHP-V
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
MESGNVSSSLFGNVSTALRPE----ARLSA---E---TRLLGWNVPP-------------
-------------------------------EELR---HIPEHWLTYPE-----------
--PPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVK
--TPIFIYNSFH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEG
--KMTHGKAIAMIIFIYMYATPW-VVACYTETWG-----RFVPEGYLTSCTFDYLTDN--
FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMNVESLR-------
------------------------------------------------------------
------------------------------------------------------------
SNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAF--GDKTL-LTPGATMIPAC
ACKMVACIDPFVYAISHPRYRMELQKRCPWL--ALNEKAPESSA----VASTST---TQE
P-----------------------------------------------------------
-----------------------------------QQT-------TA-A
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
MEYHNVSSVL-GNVSSVLRPD----ARLSA---E---SRLLGWNVPP-------------
-------------------------------DELR---HIPEHWLIYPE-----------
--PPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMMMIK
--TPIFIYNSFH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPMEG
--KMTHGKAIAMIIFIYLYATPW-VVACYTESWG-----RFVPEGYLTSCTFDYLTDN--
FDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMNVDSLR-------
------------------------------------------------------------
------------------------------------------------------------
SNVDKSKEAAEIRIAKAAITICFLFFASWTPYGVMSLIGAF--GDKTL-LTPGATMIPAC
TCKMVACIDPFVYAISHPRYRMELQKRCPWL--AISEKAPESRA----AISTST---TQE
Q-----------------------------------------------------------
-----------------------------------QQT-------TA-A
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
ME------PLCNASEPPLRPE----AR-SSGNGD---LQFLGWNVPP-------------
-------------------------------DQIQ---YIPEHWLTQLE-----------
--PPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK
--APIF--NSFH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR
--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYLTSCSFDYLSDN--
FDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLR-------
------------------------------------------------------------
------------------------------------------------------------
SNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAF--GDKSL-LTQGATMIPAC
TCKLVACIDPFVYAISHPRYRLELQKRCPWL--GVNEKSGEISS----AQSTTT---QEQ
------------------------------------------------------------
-----------------------------------QQT-------TA-A
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
MD------ALCNASEPPLRPE----ARMSSGSDE---LQFLGWNVPP-------------
-------------------------------DQIQ---YIPEHWLTQLE-----------
--PPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK
--APIFIYNSFH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR
--NMTFTKAVIMNIIIWLYCTPW-VVLPLTQFWD-----RFVPEGYLTSCSFDYLSDN--
FDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKALREQAKKMNVESLR-------
------------------------------------------------------------
------------------------------------------------------------
SNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLIGAF--GDKSL-LTPGATMIPAC
TCKLVACIEPFVYAISHPRYRMELQKRCPWL--GVNEKSGEASS----AQSTTT---QEQ
T-----------------------------------------------------------
-----------------------------------QQT-------SA-A
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
MT-----------NATGPQMAYYGAASMDFGYPE---GVSIVDFVRP-------------
-------------------------------EIKP---YVHQHWYNYPP-----------
--VNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIMLTT
N-VPFFTYNCFSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNG
P-KLTTGKAVVFALISWVIAIGC-ALPPFFG-WG-----NYILEGILDSCSYDYLTQD--
FNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKMNVSTLR-------
------------------------------------------------------------
------------------------------------------------------------
S-NEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVM--GDTSG-ITPLVSTLPAL
LAKSCSCYNPFVYAISHPKYRLAITQHLPWF--CVHETETKSND----DSQSNS---TVA
Q-----------------------------------------------------------
---------------------------------------------DK-A
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
MA-----------NVTGPQMAFYGSGAATFGYPE---GMTVADFVPD-------------
-------------------------------RVKH---MVLDHWYNYPP-----------
--VNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTT
N-FPPFCYNCFSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNG
P-KLTQGKATFMCGLAWVISVGW-SLPPFFG-WG-----SYTLEGILDSCSYDYFTRD--
MNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKMNVTNLR-------
------------------------------------------------------------
------------------------------------------------------------
S-NEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLL--GNAEG-ITPLLTTLPAL
LAKSCSCYNPFVYAISHPKFRLAITQHLPWF--CVHEKDPNDVE----ENQSSN---TQT
Q-----------------------------------------------------------
---------------------------------------------EK-S
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
ME-----SFAVAAAQLGPHFA-----PLS--------NGSVVDKVTP-------------
-------------------------------DMAH---LISPYWNQFPA-----------
--MDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT
N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG
R-PMTIPLALGKM---------------------------YVPEGNLTSCGIDYLERD--
WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLF--KF-EG-LTPLNTIWGAC
FAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFGKVDDGKSS----DAQSQA-TASEA
E-----------------------------------------------------------
---------------------------------------------SK-A
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
ME-----SFAVAAAQLGPHFA-----PLS--------NGSVVDKVTP-------------
-------------------------------DMAH---LISPYWNQFPA-----------
--MDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT
N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG
R-PMTIPLALGKIAYIWFMSSIW-CLAPAFG-WS-----RYVPEGNLTSCGIDYLERD--
WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLF--KF-EG-LTPLNTIWGAC
FAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFGKVDDGKSS----DAQSQA-TASEA
E-----------------------------------------------------------
---------------------------------------------SK-A
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
MD-----SFAAVATQLGPQFA-----APS--------NGSVVDKVTP-------------
-------------------------------DMAH---LISPYWDQFPA-----------
--MDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMIT
N-TPMMGINLYF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG
R-PMTIPLALGKIAYIWFMSTIWCCLAPVFG-WS-----RYVPEGNLTSCGIDYLERD--
WNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SEDADKSAEGKLAKVALVTISLWFMAWTPYLVINCMGLF--KF-EG-LTPLNTIWGAC
FAKSAACYNPIVYGISHPKYRLALKEKCPCC--VFGKVDDGKSS----EAQSQA-TTSEA
E-----------------------------------------------------------
---------------------------------------------SK-A
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
MERSHLPETPFDLAHSGPRFQ-----AQSSG------NGSVLDNVLP-------------
-------------------------------DMAH---LVNPYWSRFAP-----------
--MDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMAS
Q-SPVMIINFYY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGING
T-PMTIKTSIMKILFIWMMAVFW-TVMPLIG-WS-----AYVPEGNLTACSIDYMTRM--
WNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLF--KI-DG-LTPLTTIWGAT
FAKTSAVYNPIVYGISHPKYRIVLKEKCPMC--VFGNTDEPKPD----APASDTETTSEA
D-----------------------------------------------------------
---------------------------------------------SK-A
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
MERSLLPEPPLAMALLGPRFE-----AQTGG------NRSVLDNVLP-------------
-------------------------------DMAP---LVNPHWSRFAP-----------
--MDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMAS
Q-SPVMIINFYY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGING
T-PMTIKTSIMKIAFIWMMAVFW-TIMPLIG-WS-----SYVPEGNLTACSIDYMTRQ--
WNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKAMRDQAKKMNVKSLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SEDCDKSAENKLAKVALTTISLWFMAWTPYLIICYFGLF--KI-DG-LTPLTTIWGAT
FAKTSAVYNPIVYGISHPNDRLVLKEKCPMC--VCGTTDEPKPD----APPSDTETTSEA
E-----------------------------------------------------------
---------------------------------------------SK-D
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
MI-----------AVSGPSYE-----AFSYGGQARFNNQTVVDKVPP-------------
-------------------------------DMLH---LIDANWYQYPP-----------
--LNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLMMFC
M-SPPMVINCYY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSG
K-PLSINGALIRIIAIWLFSLGW-TIAPMFG-WN-----RYVPEGNMTACGTDYFNRG--
LLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKMNVASLR-------
------------------------------------------------------------
------------------------------------------------------------
S-SENQNTSAECKLAKVALMTISLWFMAWTPYLVINFSGIF--NL-VK-ISPLFTIWGSL
FAKANAVYNPIVYGISHPKYRAALFAKFPSL--AC-AAEPSSDA----VSTTSG-TTTVT
D-----------------------------------------------------------
----------------------------------NEK--------SN-A
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
M-------------ANQLSYS-----SLGWPYQP---NASVVDTMPK-------------
-------------------------------EMLY---MIHEHWYAFPP-----------
--MNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAF
M-MPTMTSNCFA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAA
A-PLTHKKATLLLLFVWIWSGGW-TILPFFG-WS-----RYVPEGNLTSCTVDYLTKD--
WSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKMNVASLR-------
------------------------------------------------------------
------------------------------------------------------------
ANADQQKQSAECRLAKVAMMTVGLWFMAWTPYLIISWAGVF--SSGTR-LTPLATIWGSV
FAKANSCYNPIVYGISHPRYKAALYQRFPSL--ACGSGESGSDV----KSEASA-TTTME
E-----------------------------------------------------------
----------------------------------KPKI-------PE-A
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
MV-------------ESTTLV-----NQTWWY-----NPTV-------------------
--------------------------------------DIHPHWAKFDP-----------
--IPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAI
NGFPLKTISAFM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAA
SKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-WG-----AYVPEGILTSCSFDYLSTD--
PSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKEMAAMAKRLNAKELR-------
------------------------------------------------------------
------------------------------------------------------------
K-AQ-AGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQF--GPAEW-VTPYAAELPVL
FAKASAIHNPIVYSVSHPKFREAIQTTFPWLLTCCQFDEKECED----ANDAEEEVVASE
R--GGESRDAAQMKEMMAMMQKMQAQQAAYQP---PPPPQGYPPQGYPPQGAYPPPQGYP
PQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQA-------YQ-A
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
MG-------------RDLR-D-----NETWWY-----NPSI-------------------
--------------------------------------VVHPHWREFDQ-----------
--VPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLV
NGFPLMTISCFL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAA
SKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-WG-----AYTLEGVLCNCSFDYISRD--
STTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELR-------
------------------------------------------------------------
------------------------------------------------------------
K-AQ-AGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQF--GPLEW-VTPYAAQLPVM
FAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETED----DKDAETEIPAGE
SSDAAPSADAAQMKEMMAMMQKMQQQQAAYPPQGYAPPPQGYPPQGYPPQGY--PPQGYP
PQGYPP---PPQGAPPQGAPP------AAPPQGVDNQA-------YQ-A
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDG-----------------GADPVAGS
WAPHLLS------------------------EVTAS---PAPTW---DAPPDNASGCGEQ
INYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA
V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY
PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKVCLISQDF------
----GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------------PGFP
RVEPDSVIALNG------------------------------------------------
----IVKLQKE------------------VEECAN------------------LSRLLKH
ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLW
LGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFV
L-----------------------------------------------------------
-----------------------------------QNADYCRKKGHD-S
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
------------------------------------------------------------
-MPHLLSGFL---------------------EVTAS---PAPTW---DAPPDNVSGCGEQ
INYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVA
V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY
PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKVCLISQDF------
----GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------------PGFP
RVQPESVISLNG------------------------------------------------
----VVKLQKE------------------VEECAN------------------LSRLLKH
ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLW
LGYANSLINPFIYAFFNRDLRPTSRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFV
L-----------------------------------------------------------
-----------------------------------QNSDHCGKKGHD-T
>    31=p A47425 serotonin receptor 5HT-7 - rat
------------------------------------------------------------
-MPHLLSGFL---------------------EVTAS---PAPTW---DAPPDNVSGCGEQ
INYGRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVA
V-MPFVSVTDLIGGKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY
PVRQNGKCMAKMILSVWLLSASI-TLPPLFG-WA-----QNVNDDKVCLISQDF------
----GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF--------------PGFP
RVQPESVISLNG------------------------------------------------
----VVKLQKE------------------VEECAN------------------LSRLLKH
ERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLW
LGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFV
L-----------------------------------------------------------
-----------------------------------QNSDHCGKKGHD-T
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
MDVLSPG-----------------------------------------------------
--------------------QGNNT------TSPPAPFETGGNTTGISD-----------
--VTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVL
V-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY
VNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTPEDRSDPD---ACTISKDH------
----GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQ
PKK-----SVNG--ESGSRNWRLGVESKAGGALCANGAVRQGDDGAAL--EVIEVHRVGN
SKEHLPLPSEAGPTPCAPAS------------------FERKNERNA-------------
EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSCH-MPTLLGAIINW
LGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF----------------------------
------------------------------------------------------------
-------------------------------------------CR---Q
>    33=p A35181 serotonin receptor class 1A - rat
MDVFSFG-----------------------------------------------------
--------------------QGNNT------TASQEPFGTGGNVTSISD-----------
--VTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVL
V-LPMAALYQVL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDY
VNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTPEDRSDPD---ACTISKDH------
----GYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPP
PKK-----SLNG--QPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATL--EVIEVHRVGN
SKEHLPLPSESGSNSYAPAC------------------LERKNERNA-------------
EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPF-CESSCH-MPALLGAIINW
LGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKF----------------------------
------------------------------------------------------------
-------------------------------------------CR---R
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
MANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTGLVTSDFNDSYGLTGQFINGS
HSSRSRD-----------NASANDT------SATNM---TDDRYWSLTV-----------
--YSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVL
V-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDY
IRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDPNN--DPDKTGTCIISQDK------
----GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEETTLVASP
KTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPENANGVNSNSS
SSERLKQIQIETAEAFANGCAEEASIAMLERQCNNGKKISSNDTPYS-------------
RTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPE-G-IPPFARSFVLW
LGYFNSLLNPIIYTIFSPEFRSAFQKILFGKY----------------------------
------------------------------------------------------------
-------------------------------------------RRGH-R
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
MANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTGLVTSDFNDSYGLTGQFINGS
HSSRSRD-----------NASANDT------SATNM---TDDRYWSLTV-----------
--YSHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVL
V-MPLSVVSEIS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDY
IRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDPNN--DPDKTGTCIISQDK------
----GYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEETTLVASP
KTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKKNRAKKLPENANGVNSNSS
SSERLKQIQIETAEAFANGCAEEASIAMLERQCNNGKKISSNDTPYS-------------
RTREKLELKRERKAARTLAIITGAFLICWLPFFIIALIGPF-VDPE-G-IPPFARSFVLW
LGYFNSLLNPIIYTIFSPEFRSAFQKILFGKY----------------------------
------------------------------------------------------------
-------------------------------------------RRGH-R
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
M--------------------------------------------------------EGA
EGQEELDWEALYLRLPLQNCSWNSTGWEPNWNVTVV---PNTTWWQASAPFDTP------
--AALVRAAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACL
V-MPLGAVYEVV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTN-IDY
IHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDLRCVVSQDV------
----GYQIFATASSFYVPVLIILILYWRIYQTARKRIRR------RRGATARGGVGPPPV
PAG---------------------------------GALVAGGGSGGIAAAVVAV-----
IGRPLPTISETTTTGFTNVSSNNTSPE--KQSCANGLEADPPTTGYGAVAAAYYPSLVRR
KPKEAADSKRERKAAKTLAIITGAFVACWLPFFVLAILVPT-CD--CE-VSPVLTSLSLW
LGYFNSTLNPVIYTVFSPEFRHAFQRLLCGRR----------------------------
------------------------------------------------------------
----------------------------------------VRRRRAP-Q
